Seattle Grace Hospital welcomes a new batch of interns, Meredith Gray (Ellen Pompeo), Christina Young (Sandra Oh), Isobel Steven (Katherine Heigl), George Melly (T· R. Knight (T.R. Knight) and Alex Carlle (Justin Chambers), five medical school friends graduated at the same time and need to compete for official residency seats with good performance. At the beginning of entering the hospital, Meredith was devastated to discover that the man who had had a one-night stand with her in the bar the night before was actually neurosurgeon Derick Sherber (Patrick Dempsey), and the entanglement between the two began; Christina attracted the attention of thoracic surgeon Preston Burke because they were equally arrogant and ambitious; George is quietly in love with Meredith; The beautiful Isobel immediately set off rumors that the one-year internship period was destined to be full of high-density pressure competition and hormonal ......